Article
Clinical expression of LRRK2 G2019S mutations in the elderly.
Movement disorders : official journal of the Movement Disorder Society - 15 Nov 2010
San Luciano Marta, Lipton Richard B, Wang Cuiling, Katz Mindy, Zimmerman Molly E, Sanders Amy E, Ozelius Laurie J, Bressman Susan B, Saunders-Pullman Rachel
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2, PARK8) are the most commonly identified monogenic etiology of Parkinson disease (PD). Over-represented in the Ashkenazi Jewish population, these mutations are transmitted in an autosomal dominant manner with age-dependent reduced penetrance. The natural history and penetrance of these mutations in the elderly is controversial and inadequately studied. We...
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