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Article

Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.

Neurology - 28 Nov 2006

Clark L N, Wang Y, Karlins E, Saito L, Mejia-Santana H, Harris J, Louis E D, Cote L J, Andrews H, Fahn S, Waters C, Ford B, Frucht S, Ottman R, Marder K

Abstract excerpt

OBJECTIVE: To evaluate the frequency of leucine-rich repeat kinase gene (LRRK2) mutations and single nucleotide polymorphisms (SNPs) in early-onset Parkinson disease (EOPD) and late-onset Parkinson disease (LOPD). METHODS: We genotyped five previously reported LRRK2 mutations (G2019S, L1114L, I1122V, R1441C, and Y1699C) and 17 coding SNPs for haplotype analysis in 504 cases with PD and 314 controls enrolled in...

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PMID: 17050822
DOI: 10.1212/01.wnl.0000244345.49809.36

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