Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure.

Abstract excerpt

PURPOSE OF REVIEW: Genetic association studies which survey the entire genome have become a common design for uncovering the genetic basis of common diseases, including lipid-related traits. Such studies have identified several novel loci which influence blood lipids. The present review highlights the statistical challenges associated with such large-scale genetic studies and discusses the available...

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