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Article

Inactivation of the WASF3 gene in prostate cancer cells leads to suppression of tumorigenicity and metastases

17 Aug 2010

Abstract excerpt

BACKGROUND: The WASF3 protein is involved in cell movement and invasion, and to investigate its role in prostate cancer progression we studied the phenotypic effects of knockdown in primary tumors and cell lines. METHODS: ShRNA was used to knockdown WASF3 function in prostate cell lines. Cell motility (scratch wound assay), anchorage independent growth and in vivo tumorigenicity and metastasis were then compared...

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PMID: 20717117
DOI: 10.1038/sj.bjc.6605850

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