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Phenotypic alterations of 7,12-dimethylbenz(a)anthracene and N-methyl-N-nitrosourea induced rat mammary tumors during repeated transplantations.

In vivo (Athens, Greece) - 1 Jan 2000

Dolezalová V, Nĕmecek R, Tóth J, Sugár J

Abstract excerpt

New transplantable rat mammary tumor lines derived from 7,12-dimethylbenz(a)anthracence (DMBA)- and N-methyl-N-nitrosourea (MNU)-induced carcinogenesis were established and characterized for biological and morphological criteria in the course of multiple tumor generations growing in female or male Wistar rats. DMBA-derived tumors RMT-1, RMT-2 and RMT-3 converted from adenocarcinoma to fibrosarcoma in the early...

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PMID: 2979793

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