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Article

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis.

Nature - 3 Jun 2010

Cheloufi Sihem, Dos Santos Camila O, Chong Mark M W, Hannon Gregory J

Abstract excerpt

The nucleolytic activity of animal Argonaute proteins is deeply conserved, despite its having no obvious role in microRNA-directed gene regulation. In mice, Ago2 (also known as Eif2c2) is uniquely required for viability, and only this family member retains catalytic competence. To investigate the evolutionary pressure to conserve Argonaute enzymatic activity, we engineered a mouse with catalytically inactive Ago2...

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Identifiers

PMID: 20424607
DOI: 10.1038/nature09092
PMCID: PMC2995450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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