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The RNase III Enzyme DROSHA Is Essential for MicroRNA Production and Spermatogenesis

5 Jun 2012

Abstract excerpt

DROSHA is a nuclear RNase III enzyme responsible for cleaving primary microRNAs (miRNAs) into precursor miRNAs and thus is essential for the biogenesis of canonical miRNAs. DICER is a cytoplasmic RNase III enzyme that not only cleaves precursor miRNAs to produce mature miRNAs but also dissects naturally formed/synthetic double-stranded RNAs to generate small interfering RNAs (siRNAs). To investigate the role of...

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PMID: 22665486
DOI: 10.1074/jbc.m112.362053

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