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Article

Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections.

PloS one - 11 May 2010

Zhong Weimin, Liu Feng, Dong Libo, Lu Xiuhua, Hancock Kathy, Reinherz Ellis L, Katz Jacqueline M, Sambhara Suryaprakash

Abstract excerpt

BACKGROUND: Memory CD8 T cells to influenza A viruses are widely detectable in healthy human subjects and broadly cross-reactive for serologically distinct influenza A virus subtypes. However, it is not clear to what extent such pre-existing cellular immunity can provide cross-subtype protection against novel emerging influenza A viruses. METHODOLOGY/PRINCIPAL FINDINGS: We show in the mouse model that naturally...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20485501
DOI: 10.1371/journal.pone.0010583
PMCID: PMC2868023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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