Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cycle influenza virus vaccine generates lung CD8 + Trm that cross-react against viral variants and subvert virus escape mutants

8 Sept 2023

Abstract excerpt

Influenza virus–specific tissue-resident memory (Trm) CD8 + T cells located along the respiratory tract provide cross-strain protection against a breadth of influenza viruses. We show that immunization with a single-cycle influenza virus vaccine candidate (S-FLU) results in the deposition of influenza virus nucleoprotein (NP)–specific CD8 + Trm along the respiratory tract that were more cross-reactive against...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza Virus Research Studies
Share to Respiratory viral infections research
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37683004
DOI: 10.1126/sciadv.adg3469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cycle influenza virus vaccine generates lung CD8 + Trm that cross-react against viral variants and subvert virus escape mutantsPMID 37683004Read ↗

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.Semantic proximity Read ↗

Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study.Semantic proximity Read ↗

CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and ageSemantic proximity Read ↗

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccineSemantic proximity Read ↗

Analyses of the Specificity of CD4 T Cells During the Primary Immune Response to Influenza Virus Reveals Dramatic MHC-Linked Asymmetries in Reactivity to Individual Viral ProteinsSemantic proximity Read ↗

Molecular basis for universal HLA-A*0201–restricted CD8 <sup>+</sup> T-cell immunity against influenza virusesSemantic proximity Read ↗

Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability.Semantic proximity Read ↗

Truncation of NS1 Protein Enhances T Cell-Mediated Cross-Protection of a Live Attenuated Influenza Vaccine Virus Expressing Wild-Type NucleoproteinSemantic proximity Read ↗

A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation.Semantic proximity Read ↗

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 diseaseSemantic proximity Read ↗

Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza VaccinesSemantic proximity Read ↗

Potential killers exposed: tracking endogenous influenza-specific CD8+ T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.