Article
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
Nature genetics - 1 Sept 2010
Hamza Taye H, Zabetian Cyrus P, Tenesa Albert, Laederach Alain, Montimurro Jennifer, Yearout Dora, Kay Denise M, Doheny Kimberly F, Paschall Justin, Pugh Elizabeth, Kusel Victoria I, Collura Randall, Roberts John, Griffith Alida, Samii Ali, Scott William K, Nutt John, Factor Stewart A, Payami Haydeh
Abstract excerpt
Parkinson's disease is a common disorder that leads to motor and cognitive disability. We performed a genome-wide association study of 2,000 individuals with Parkinson's disease (cases) and 1,986 unaffected controls from the NeuroGenetics Research Consortium (NGRC). We confirmed associations with SNCA and MAPT, replicated an association with GAK (using data from the NGRC and a previous study, P = 3.2 x 10(-9))...
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