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Article

Fine mapping of the HLA locus in Parkinson’s disease in Europeans

21 Sept 2021

Abstract excerpt

Abstract We fine mapped the leukocyte antigen ( HLA) region in 13,770 Parkinson’s disease (PD) patients, 20,214 proxy-cases, and 490,861 controls of European origin. Four HLA types were associated with PD after correction for multiple comparisons, HLA-DQA1 *03:01, HLA-DQB1 *03:02, HLA-DRB1 *04:01, and HLA-DRB1 *04:04. Haplotype analyses followed by amino acid analysis and conditional analyses suggested that the...

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PMID: 34548497
DOI: 10.1038/s41531-021-00231-5

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