Association of Parkinson disease with structural and regulatory variants in the HLA region.

doi:10.1016/j.ajhg.2013.10.009

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Article

Association of Parkinson disease with structural and regulatory variants in the HLA region.

American journal of human genetics - 7 Nov 2013

Wissemann William T, Hill-Burns Erin M, Zabetian Cyrus P, Factor Stewart A, Patsopoulos Nikolaos, Hoglund Bryan, Holcomb Cherie, Donahue Ryan J, Thomson Glenys, Erlich Henry, Payami Haydeh

Abstract excerpt

Historically, association of disease with the major histocompatibility complex (HLA) genes has been tested with HLA alleles that encode antigen-binding affinity. The association with Parkinson disease (PD), however, was discovered with noncoding SNPs in a genome-wide association study (GWAS). We show here that several HLA-region SNPs that have since been associated with PD form two blocks tagged by rs3129882 (p =...

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Identifiers

PMID: 24183452
DOI: 10.1016/j.ajhg.2013.10.009
PMCID: PMC3824116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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