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Article

Association between Parkinson's disease and the HLA-DRB1 locus.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2012

Ahmed Ismaïl, Tamouza Ryad, Delord Marc, Krishnamoorthy Rajagopal, Tzourio Christophe, Mulot Claire, Nacfer Magali, Lambert Jean-Charles, Beaune Philippe, Laurent-Puig Pierre, Loriot Marie-Anne, Charron Dominique, Elbaz Alexis

Abstract excerpt

Two genome-wide association studies (GWASs) recently highlighted the HLA-DRA and HLA-DRB5 genes as associated with Parkinson disease (PD). However, because HLA-DRA displays a low level of polymorphisms and HLA-DRB5 is only present in approximately 20% of the population, these findings are difficult to interpret. Our aims were: (1) to replicate and investigate in greater detail the association between PD and the...

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PMID: 22807207
DOI: 10.1002/mds.25035

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