Article
Genotyping, Platelet Activation, and Cardiovascular Outcome in Patients after Percutaneous Coronary Intervention: Two Pieces of the Puzzle of Clopidogrel Resistance.
Cardiology - 1 Jan 2000
Siasos Gerasimos, Oikonomou Evangelos, Vavuranakis Manolis, Kokkou Eleni, Mourouzis Konstantinos, Tsalamandris Sotiris, Zaromitidou Marina, Kioufis Stamatios, Tsigkou Vasiliki, Deftereos Spyridon, Stefanadis Christodoulos, Tousoulis Dimitris
Abstract excerpt
OBJECTIVES: Individual platelet responses to antiplatelet therapy depend on genetic, cellular, and clinical factors. CYP2C19 and P2Y12 receptor polymorphisms are implicated in platelet responses to antiplatelet treatment. We aimed to evaluate the impact of CYP2C19 and C34T P2Y12 genotyping on platelet reactivity and cardiovascular outcome in patients after percutaneous coronary intervention (PCI) on clopidogrel...
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