Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti‐retroviral activity of TRIM5α

4 Jan 2010

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) shows a very narrow host range limited to humans and chimpanzees. Experimentally, HIV-1 does not infect Old World monkeys, such as rhesus (Rh) and cynomolgus (CM) monkeys, and fails to replicate in activated CD4 positive T lymphocytes obtained from these monkeys. In contrast, simian immunodeficiency virus isolated from a macaque monkey (SIVmac) can replicate well in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20049904
DOI: 10.1002/rmv.637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti‐retroviral activity of TRIM5αPMID 20049904Read ↗

TRIM5α and Species Tropism of HIV/SIVSemantic proximity Read ↗

Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and SpecificitySemantic proximity Read ↗

Contribution of RING domain to retrovirus restriction by TRIM5alpha depends on combination of host and virus.Semantic proximity Read ↗

TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys.Semantic proximity Read ↗

The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.Semantic proximity Read ↗

The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5alpha.Semantic proximity Read ↗

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor FunctioningSemantic proximity Read ↗

Functional Replacement of the RING, B-Box 2, and Coiled-Coil Domains of Tripartite Motif 5α (TRIM5α) by Heterologous TRIM DomainsSemantic proximity Read ↗

The Antiviral Spectra of TRIM5α Orthologues and Human TRIM Family Proteins against Lentiviral ProductionSemantic proximity Read ↗

Silencing of tripartite motif protein (TRIM) 5alpha mediated anti-HIV-1 activity by truncated mutant of TRIM5alpha.Semantic proximity Read ↗

A dominant-negative effect of cynomolgus monkey tripartite motif protein TRIM5alpha on anti-simian immunodeficiency virus SIVmac activity of an African green monkey orthologue.Semantic proximity Read ↗

Role of TRIM5α RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.