Article

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

2019-03-25

Abstract excerpt

The capsid (CA) protein lattice of HIV-1 and other retroviruses encases viral genomic RNA and regulates steps that are essential to retroviral invasion of target cells, including reverse transcription, nuclear trafficking, and integration of viral cDNA into host chromosomal DNA 1 . Cyclophilin A (CypA), the first cellular protein reported to bind HIV-1 CA 2 , has interacted with invading lentiviruses related to...

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Literature Corpus work: 5490a446-c076-5a97-be3f-97509f6ed4dc
DOI: 10.1101/587907

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