Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Serotonin transporter gene and stress reactivity in unipolar depression. Role of the HPA system as endophenotype of the SLC6A4 gene].

Der Nervenarzt - 1 Mar 2014

Welper H, Aller A, Guttenthaler V, Höfels S, Lennertz L, Pfeiffer U, Schwab S G, Zobel A

Abstract excerpt

BACKGROUND: A length polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with both depression and hypothalamic-pituitary-adrenal (HPA) system activity. A dysregulation of the HPA system is considered to be a candidate endophenotype of depression. The objective of the present study was an investigation of a possible gene-endophenotype-interaction between 5-HTTLPR and HPA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corticotropin-Releasing Hormone
Share to Depressive Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dexamethasone

Share to Endophenotypes

Share to Hypothalamo-Hypophyseal System

Share to Pituitary-Adrenal System

Share to Serotonin Plasma Membrane Transport Proteins

Share to Stress, Psychological

Source

Identifiers

PMID: 23325311
DOI: 10.1007/s00115-012-3702-7

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Serotonin transporter gene and stress reactivity in unipolar depression. Role of the HPA system as endophenotype of the SLC6A4 gene].PMID 23325311Read ↗

[Stress and depression: clinical, neurobiological and genetical perspectives].Semantic proximity Read ↗

[Depression and stress: is there an endophenotype?].Semantic proximity Read ↗

Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression.Semantic proximity Read ↗

Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction.Semantic proximity Read ↗

[Serotonin transporter gene polymorphism modulates psychic maladaptation in relatives of patients with endogenic psychoses].Semantic proximity Read ↗

Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression.Semantic proximity Read ↗

Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression?Semantic proximity Read ↗

An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings.Semantic proximity Read ↗

Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion.Semantic proximity Read ↗

Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA.Semantic proximity Read ↗

Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders.Semantic proximity Read ↗

Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.