PCLO gene: its role in vulnerability to major depressive disorder.

doi:10.1016/j.jad.2012.01.028

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

PCLO gene: its role in vulnerability to major depressive disorder.

Journal of affective disorders - 1 Aug 2012

Minelli Alessandra, Scassellati Catia, Cloninger Claude Robert, Tessari Elisabetta, Bortolomasi Marco, Bonvicini Cristian, Giacopuzzi Mario, Frisoni Giovanni Battista, Gennarelli Massimo

Abstract excerpt

BACKGROUND: A recent genome-wide association study on Major Depressive Disorder (MDD) identified a specific association with a non-synonymous polymorphism (rs2522833) of a gene encoding the presynaptic protein piccolo (PCLO). A high percentage of patients who develop MDD have particular temperamental traits, such as passivity, pessimism, indecisiveness, and low self-esteem, which are related to the subsequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Depressive Disorder, Major

Share to Genome-Wide Association Study

Share to Homozygote

Share to Neuropeptides

Share to Personality Inventory

Share to Temperament

Source

Open in PubMed

Identifiers

PMID: 22386049
DOI: 10.1016/j.jad.2012.01.028

Genes

PCLO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PCLO gene: its role in vulnerability to major depressive disorder.PMID 22386049Read ↗

Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder.Semantic proximity Read ↗

Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.Semantic proximity Read ↗

The genetics of major depression: moving beyond the monoamine hypothesis.Semantic proximity Read ↗

The genetics of depression and related traits.Semantic proximity Read ↗

The PCLO gene and depressive disorders: replication in a population-based study.Semantic proximity Read ↗

PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.Semantic proximity Read ↗

The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders.Semantic proximity Read ↗

A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.Semantic proximity Read ↗

Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.Semantic proximity Read ↗

Association of genetic polymorphisms with personality profile in individuals without psychiatric disorders.Semantic proximity Read ↗

PCLO rs2522833 impacts HPA system activity in healthy young adults.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.