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Article

FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder.

Journal of psychiatric research - 1 Sept 2018

Ferrer Alex, Costas Javier, Labad Javier, Salvat-Pujol Neus, Segalàs Cinto, Urretavizcaya Mikel, Real Eva, de Arriba-Arnau Aida, Alonso Pino, Crespo José M, Barrachina Marta, Soriano-Mas Carles, Carracedo Ángel, Menchón José M, Soria Virginia

Abstract excerpt

Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) have both been linked to abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. Polymorphisms in the genes involved in HPA axis activity, such as FKBP5, and their interactions with childhood trauma have been associated with stress-related mental disorders. Our goal was to study the role of FKBP5 genetic variants in HPA axis negative...

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Source

Identifiers

PMID: 30107269
DOI: 10.1016/j.jpsychires.2018.08.003

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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