Article
Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility.
BMC cancer - 11 Aug 2010
Trubicka Joanna, Grabowska-Kłujszo Ewa, Suchy Janina, Masojć Bartłomiej, Serrano-Fernandez Pablo, Kurzawski Grzegorz, Cybulski Cezary, Górski Bohdan, Huzarski Tomasz, Byrski Tomasz, Gronwald Jacek, Złowocka Elzbieta, Kładny Józef, Banaszkiewicz Zbigniew, Wiśniowski Rafał, Kowalska Elzbieta, Lubinski Jan, Scott Rodney J
Abstract excerpt
BACKGROUND: CYP1B1 is a P450 enzyme which is involved in the activation of pro-carcinogens to carcinogens as well as sex hormone metabolism. Because differences in the activity of the enzyme have been correlated with variant alleles of single nucleotide polymorphisms (SNPs), it represents an attractive candidate gene for studies into colorectal cancer susceptibility. METHODS: We genotyped 597 cancer patients and...
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