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Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women.

Pharmacogenetics and genomics - 1 Aug 2006

Gaudet Mia M, Chanock Stephen, Lissowska Jolanta, Berndt Sonja I, Yang Xiaohong Rose, Peplonska Beata, Brinton Louise A, Welch Robert, Yeager Meredith, Bardin-Mikolajczak Alicja, Sherman Mark E, Sutter Thomas R, Garcia-Closas Montserrat

Abstract excerpt

Four single nucleotide polymorphisms (SNPs) in CYP1B1 (Ex2 + 143 C > G, Ex2 + 356 G > T, Ex3 + 251 G > C, Ex3 + 315 A > G) cause amino acid changes (R48G, A119S, L432V and N453S, respectively) and are associated with increased formation of catechol estrogens; however, epidemiologic evidence only weakly supports an association between these variants and breast cancer risk. Because genetic variability conferring...

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PMID: 16847423
DOI: 10.1097/01.fpc.0000215067.29342.6f

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