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Article

Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms.

Journal of biomedical science - 4 Sept 2014

Martinelli Marcella, Scapoli Luca, Cura Francesca, Rodia Maria Teresa, Ugolini Giampaolo, Montroni Isacco, Solmi Rossella

Abstract excerpt

BACKGROUND: The ATP-binding cassette transporter B1 (ABCB1) gene codes for a membrane efflux pump localized in epithelial cells. Together with other Permeability-glycoproteins in the small and large intestine, its product represents a barrier against xenobiotics, bacterial toxins, drugs and other substances introduced with diet, including carcinogens. The aim of this investigation was to verify the possible...

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Identifiers

PMID: 25355168
DOI: 10.1186/s12929-014-0089-8
PMCID: PMC4428509

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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