Article
Polymorphisms of the CYP1B1 gene and hepatocellular carcinoma risk in a Chinese population.
Gene - 10 Jun 2015
Liu Fei, Luo Li-Mei, Wei Yong-Gang, Li Bo, Wang Wen-Tao, Wen Tian-Fu, Yang Jia-Yin, Xu Ming-Qing, Yan Lv-Nan
Abstract excerpt
BACKGROUND: CYP1B1 is a P450 enzyme which is involved in the activation of pro-carcinogens to carcinogens as well as estrogen metabolism. We hypothesized that genetic variants in CYP1B1 may modify individual susceptibility to hepatocellular carcinoma (HCC). METHODS: To test this hypothesis, we evaluated the associations of three CYP1B1 single nucleotide polymorphisms (SNPs) and HCC risk in a case-control study of...
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