Article
Genetic loci for bone architecture determined by three-dimensional CT in crosses with the diabetic GK rat.
Bone - 1 Dec 2010
Lagerholm Sofia, Park Hee-Bok, Luthman Holger, Nilsson Mats, McGuigan Fiona, Swanberg Maria, Akesson Kristina
Abstract excerpt
The F344 rat carries alleles contributing to bone fragility while the GK rat spontaneously develops type-2 diabetes. These characteristics make F344×GK crosses well suited for the identification of genes related to bone size and allow for future investigation on the association with type-2 diabetes. The aim of this study was to identify quantitative trait loci (QTLs) for bone size phenotypes measured by a new...
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