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Dynamic genetic architecture of metabolic syndrome attributes in the rat.

Physiological genomics - 14 Apr 2005

Seda Ondrej, Liska Frantisek, Krenova Drahomira, Kazdova Ludmila, Sedova Lucie, Zima Tomas, Peng Junzheng, Pelinkova Kveta, Tremblay Johanne, Hamet Pavel, Kren Vladimir

Abstract excerpt

The polydactylous rat strain (PD/Cub) is a highly inbred (F > 90) genetic model of metabolic syndrome. The aim of this study was to analyze the genetic architecture of the metabolic derangements found in the PD/Cub strain and to assess its dynamics in time and in response to diet and medication. We derived a PD/Cub x BN/Cub (Brown Norway) F2 intercross population of 149 male rats and performed metabolic profiling...

Topics

Animals
Animals, Congenic
Anti-Inflammatory Agents
Dexamethasone
Dyslipidemias
Genetic Linkage
Insulin Resistance
Male
Metabolic Syndrome
Phenotype
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred BN

Rats, Inbred Strains

Sucrose

Source

Identifiers

PMID: 15728334
DOI: 10.1152/physiolgenomics.00230.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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