Article
Genetic loci affecting bone structure and strength in inbred COP and DA rats.
Bone - 1 Mar 2008
Sun Qiwei, Alam Imranul, Liu Lixiang, Koller Daniel L, Carr Lucinda G, Econs Michael J, Foroud Tatiana, Turner Charles H
Abstract excerpt
Previous studies have shown that the Copenhagen 2331 (COP) and Dark Agouti (DA) rats have significant differences in bone structure and strength despite their similar body mass. Thus, these inbred rat strains may provide a unique resource to identify the genetics underlying the phenotypic variation in bone fragility. A sample of 828 (405 males and 423 females) COPxDA F2 progeny had extensive phenotyping for bone...
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