Article
High-resolution genome screen for bone mineral density in heterogeneous stock rat.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2014
Alam Imranul, Koller Daniel L, Cañete Toni, Blázquez Gloria, López-Aumatell Regina, Martínez-Membrives Esther, Díaz-Morán Sira, Tobeña Adolf, Fernández-Teruel Alberto, Stridh Pernilla, Diez Margarita, Olsson Tomas, Johannesson Martina, Baud Amelie, Econs Michael J, Foroud Tatiana
Abstract excerpt
We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model, suggesting that it represents a unique genetic resource for dissecting the complex genetics underlying bone fragility. The purpose of this study was to identify...
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