Article
Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2008
Alam Imranul, Sun Qiwei, Liu Lixiang, Koller Daniel L, Carr Lucinda G, Econs Michael J, Foroud Tatiana, Turner Charles H
Abstract excerpt
INTRODUCTION: Hip fracture is the most devastating osteoporotic fracture type with significant morbidity and mortality. Several studies in humans identified chromosomal regions linked to hip size and bone mass. Animal models, particularly the inbred rat, serve as complementary approaches for studying the genetic influence on hip fragility. The purpose of this study is to identify sex-independent and sex-specific...
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