Article
Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: relevance for major depression.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2012
Pap Dorottya, Gonda Xenia, Molnar Eszter, Lazary Judit, Benko Anita, Downey Darragh, Thomas Emma, Chase Diana, Toth Zoltan G, Mekli Krisztina, Platt Hazel, Payton Antony, Elliott Rebecca, Anderson Ian M, Deakin J F William, Bagdy Gyorgy, Juhasz Gabriella
Abstract excerpt
The catechol-o-methyltransferase (COMT) gene has been extensively investigated in depression with somewhat contradictory results but the role of impulsivity, as a possible intermediate phenotype in this disorder, has not been considered yet. In our study, four tagging SNPs in the COMT gene (rs933271, rs740603, rs4680, rs4646316) were genotyped in two independent population cohorts: Manchester (n = 1267) and...