Article
Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders.
Psychiatry research - 30 Nov 2008
Lafuente Amalia, Bernardo Miquel, Mas Sergi, Crescenti Anna, Aparici Monica, Gasso Patricia, Deulofeu Ramon, Mane Anna, Catalan Rosa, Carne Xavier
Abstract excerpt
OBJECTIVE: The relationship is examined of the dopamine D2 receptor (DRD2) polymorphism (TaqIA, TaqIB, -141 C Ins/Del) and the catechol-O-methyltransferase (COMT) polymorphism (A-278G, G158A) to the risk of antipsychotic-induced extrapyramidal symptoms (EPS) in schizophrenia and bipolar disorders. Participants comprised 80 cases presenting with EPS (Simpson-Angus Scale score >3) and 188 controls presenting...
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