Article
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2010
Poulogiannis George, McIntyre Rebecca E, Dimitriadi Maria, Apps John R, Wilson Catherine H, Ichimura Koichi, Luo Feijun, Cantley Lewis C, Wyllie Andrew H, Adams David J, Arends Mark J
Abstract excerpt
In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin ligase whose deficiency is responsible for a form of autosomal recessive juvenile parkinsonism. PARK2 is located on chromosome 6 (at 6q25-27), a chromosome with one of the lowest overall frequencies of DNA copy...
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