Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2004

Picchio Maria Cristina, Martin Eric Santos, Cesari Rossano, Calin George Adrian, Yendamuri Sai, Kuroki Tamotsu, Pentimalli Francesca, Sarti Manuela, Yoder Kristine, Kaiser Larry R, Fishel Richard, Croce Carlo Maria

Abstract excerpt

PURPOSE: Parkin, a gene mutated in autosomal recessive juvenile Parkinsonism and mapped to the common fragile site FRA6E on human chromosome 6q25-q27, is associated with a frequent loss of heterozygosity and altered expression in breast and ovarian carcinomas. In addition, homozygous deletions of exon 2 creating deleterious truncations of the Parkin transcript were observed in the lung adenocarcinoma cell lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Complementary
Share to Lentivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Cell Cycle

Share to Loss of Heterozygosity

Share to Mice, Nude

Share to Neoplasm Transplantation

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 15102676
DOI: 10.1158/1078-0432.ccr-03-0086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer.PMID 15102676Read ↗

<i>Parkin</i> gene alterations in hepatocellular carcinomaSemantic proximity Read ↗

A recurrent mutation in PARK2 is associated with familial lung cancer.Semantic proximity Read ↗

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.Semantic proximity Read ↗

Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cellsSemantic proximity Read ↗

Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma.Semantic proximity Read ↗

Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the Parkin gene in affected individuals.Semantic proximity Read ↗

Alterations in the common fragile site gene Parkin in ovarian and other cancersSemantic proximity Read ↗

Implication of alterations in Parkin gene among North Indian patients with colorectal cancer.Semantic proximity Read ↗

Expression pattern of parkin isoforms in lung adenocarcinomasSemantic proximity Read ↗

Pseudo-heterozygous rearrangement mutation of parkin.Semantic proximity Read ↗

Identification and validation of control cell lines for accurate parkin dosage analysis.Semantic proximity Read ↗

Porcine Parkin: molecular cloning of PARK2 cDNA, expression analysis, and identification of a splicing variant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.