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Genomic instability in the PARK2 locus is associated with Parkinson’s disease

2 Apr 2015

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder affecting mostly elderly people, although there is a group of patients developing so-called early-onset PD (EOPD). Mutations in the PARK2 gene are a common cause of autosomal recessive EOPD. PARK2 belongs to the family of extremely large human genes which are often localised in genomic common fragile sites (CFSs) and exhibit gross instability. PARK2...

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PMID: 25833766
DOI: 10.1007/s13353-015-0282-9

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