Article
Prdm5 suppresses Apc(Min)-driven intestinal adenomas and regulates monoacylglycerol lipase expression.
Oncogene - 19 Jun 2014
Galli G G, Multhaupt H A, Carrara M, de Lichtenberg K H, Christensen I B J, Linnemann D, Santoni-Rugiu E, Calogero R A, Lund A H
Abstract excerpt
PRDM proteins are tissue-specific transcription factors often deregulated in diseases, particularly in cancer where different members have been found to act as oncogenes or tumor suppressors. PRDM5 is a poorly characterized member of the PRDM family for which several studies have reported a high frequency of promoter hypermethylation in cancer types of gastrointestinal origin. We report here the characterization...
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