Identification and validation of control cell lines for accurate parkin dosage analysis.

Abstract excerpt

Mutation of the parkin gene (parkin) is the most common cause of early-onset Parkinson's disease and to date over 100 different mutations have been described. However, screening of parkin is complicated by its genomic architecture and context. Notably, dosage alterations in parkin account for greater than 50% of mutations detected in some cohort studies. To improve the accuracy and reproducibility of parkin...

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