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Article

Maintenance of pluripotency in mouse ES cells without Trp53.

Scientific reports - 15 Oct 2013

Shigeta Masaki, Ohtsuka Satoshi, Nishikawa-Torikai Satomi, Yamane Mariko, Fujii Setsuko, Murakami Kazuhiro, Niwa Hitoshi

Abstract excerpt

Tumor suppressor Trp53 works as a guardian of the genome in somatic cells. In mouse embryonic stem (ES) cells, it was reported that Trp53 represses pluripotency-associated transcription factor Nanog to induce differentiation. However, since Trp53-null mice develop to term, Trp53 is dispensable for both the maintenance and differentiation of the pluripotent stem cell population in vivo, suggesting the differential...

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Identifiers

PMID: 24126347
DOI: 10.1038/srep02944
PMCID: PMC3796736

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