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Cancer Stemness: p53 at the Wheel

11 Jan 2021

Abstract excerpt

The tumor suppressor p53 maintains an equilibrium between self-renewal and differentiation to sustain a limited repertoire of stem cells for proper development and maintenance of tissue homeostasis. Inactivation of p53 disrupts this balance and promotes pluripotency and somatic cell reprogramming. A few reports in recent years have indicated that prevalentTP53oncogenicgain-of-function(GOF) mutations further...

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PMID: 33505918
DOI: 10.3389/fonc.2020.604124

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