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Article

Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells.

Cell death & disease - 29 Dec 2016

Grespi Francesca, Landré Vivien, Molchadsky Alina, Di Daniele Nicola, Marsella Luigi Tonino, Melino Gerry, Rotter Varda

Abstract excerpt

The tumour suppressor p53 plays an important role in somatic cell reprogramming. While wild-type p53 reduces reprogramming efficiency, mutant p53 exerts a gain of function activity that leads to increased reprogramming efficiency. Furthermore, induced pluripotent stem cells expressing mutant p53 lose their pluripotency in vivo and form malignant tumours when injected in mice. It is therefore of great interest to...

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Identifiers

PMID: 28032868
DOI: 10.1038/cddis.2016.419
PMCID: PMC5260988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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