Article
The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient.
PloS one - 1 Jan 2020
Li Yang, Li Ting, Tang Yuejia, Zhan Zhiyan, Ding Lixia, Song Lili, Yu Tingting, Yang Yi, Ma Jing, Zhang Yingwen, Zhou Ying, Gu Song, Xu Min, Gao Yijin, Li Yanxin
Abstract excerpt
p53 is one of the most extensively studied proteins in cancer research. Mutations in p53 generally abolish normal p53 function, and some mutants can gain new oncogenic functions. However, the mechanisms underlying p53 mutation-driven cancer remains to be elucidated. Our study investigated the function of a heterozygous p53 mutation (p.Asn268Glufs*4) in a Li-Fraumeni syndrome (LFS) patient. We used episomal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.