Article
Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease.
Molecular psychiatry - 1 Jan 2009
Bensemain F, Hot D, Ferreira S, Dumont J, Bombois S, Maurage C-A, Huot L, Hermant X, Levillain E, Hubans C, Hansmannel F, Chapuis J, Hauw J-J, Schraen S, Lemoine Y, Buée L, Berr C, Mann D, Pasquier F, Amouyel P, Lambert J-C
Abstract excerpt
To more rapidly identify candidate genes located within chromosomal regions of interest defined by genome scan studies in Alzheimer's disease (AD), we have developed a customized microarray containing all the ORFs (n=2741) located within nine of these regions. Levels of gene expression were assessed in total RNA from brain tissue of 12 controls and 12 AD patients. Of all genes showing differential expression, we...
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