Article
Oxidative damage is the earliest event in Alzheimer disease.
Journal of neuropathology and experimental neurology - 1 Aug 2001
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj E K, Jones P K, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood C S, Petersen R B, Smith M A
Abstract excerpt
Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable neurons of patients with Alzheimer disease (AD). To determine whether oxidative damage is an early- or end-stage event in the process of neurodegeneration in AD, we investigated the relationship between neuronal 8OHG and nitrotyrosine and...
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