Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natriuretic peptide pharmacogenetics: membrane metallo-endopeptidase (MME): common gene sequence variation, functional characterization and degradation.

Journal of molecular and cellular cardiology - 1 Nov 2010

Pereira Naveen L, Aksoy Pinar, Moon Irene, Peng Yi, Redfield Margaret M, Burnett John C, Wieben Eric D, Yee Vivien C, Weinshilboum Richard M

Abstract excerpt

Membrane metallo-endopeptidase (MME), also known as neutral endopeptidase 24.11 (EC 3.4.24.11), is involved in the metabolism of natriuretic peptides that play a key role in modulating cardiac structure and function. Common genetic variation in MME has not been addressed by resequencing the gene using DNA from different ethnic populations. We set out to identify and functionally characterize common genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Natriuretic Factor
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Molecular Chaperones

Share to Neprilysin

Share to Proteasome Endopeptidase Complex

Share to Protein Processing, Post-Translational

Share to Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 20692264
DOI: 10.1016/j.yjmcc.2010.07.020
PMCID: PMC3092155

Genes

MME

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natriuretic peptide pharmacogenetics: membrane metallo-endopeptidase (MME): common gene sequence variation, functional characterization and degradation.PMID 20692264Read ↗

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.Semantic proximity Read ↗

Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.Semantic proximity Read ↗

Characterization of ADME gene variation in 21 populations by exome sequencing.Semantic proximity Read ↗

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.Semantic proximity Read ↗

A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity.Semantic proximity Read ↗

Single nucleotide polymorphism-specific regulation of matrix metalloproteinase-9 by multiple miRNAs targeting the coding exon.Semantic proximity Read ↗

A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms.Semantic proximity Read ↗

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic propertiesSemantic proximity Read ↗

The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.Semantic proximity Read ↗

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.Semantic proximity Read ↗

Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.Semantic proximity Read ↗

Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.