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Article

Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics and genomics - 1 Mar 2017

Hovelson Daniel H, Xue Zhengyu, Zawistowski Matthew, Ehm Margaret G, Harris Elizabeth C, Stocker Sophie L, Gross Annette S, Jang In-Jin, Ieiri Ichiro, Lee Jong-Eun, Cardon Lon R, Chissoe Stephanie L, Abecasis Gonçalo, Nelson Matthew R

Abstract excerpt

OBJECTIVE: Proteins involving absorption, distribution, metabolism, and excretion (ADME) play a critical role in drug pharmacokinetics. The type and frequency of genetic variation in the ADME genes differ among populations. The aim of this study was to systematically investigate common and rare ADME coding variation in diverse ethnic populations by exome sequencing. MATERIALS AND METHODS: Data derived from...

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Identifiers

PMID: 27984508
DOI: 10.1097/FPC.0000000000000260
PMCID: PMC5287433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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