Article
The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.
PLoS genetics - 1 Sept 2014
Wang Ya-Juan, Tayo Bamidele O, Bandyopadhyay Anupam, Wang Heming, Feng Tao, Franceschini Nora, Tang Hua, Gao Jianmin, Sung Yun Ju, Elston Robert C, Williams Scott M, Cooper Richard S, Mu Ting-Wei, Zhu Xiaofeng
Abstract excerpt
High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)-rs2272996-in the gene encoding vanin-1, a glycosylphosphatidylinositol (GPI)-anchored membrane pantetheinase. In the present study, we first replicated the association of rs2272996 and BP traits...
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