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Article

Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice.

Biochemical pharmacology - 15 Nov 2010

Tanaka Naoki, Zhang Xiuguo, Sugiyama Eiko, Kono Hiroyuki, Horiuchi Akira, Nakajima Takero, Kanbe Hiroki, Tanaka Eiji, Gonzalez Frank J, Aoyama Toshifumi

Abstract excerpt

Eicosapentaenoic acid (EPA) in fish oil is known to improve hepatic steatosis. However, it remains unclear whether such action of EPA is actually caused by peroxisome proliferator-activated receptor α (PPARα) activation. To explore the contribution of PPARα to the effects of EPA itself, male wild-type and Ppara-null mice were fed a saturated fat diet for 16 weeks, and highly (>98%)-purified EPA was administered...

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Identifiers

PMID: 20691165
DOI: 10.1016/j.bcp.2010.07.031
PMCID: PMC6338080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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