Article
Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2011
Nakajima Kenji, Yamashita Tomoya, Kita Tomoyuki, Takeda Masafumi, Sasaki Naoto, Kasahara Kazuyuki, Shinohara Masakazu, Rikitake Yoshiyuki, Ishida Tatsuro, Yokoyama Mitsuhiro, Hirata Ken-ichi
Abstract excerpt
OBJECTIVE: Eicosapentaenoic acid (EPA) has been shown to have beneficial effects on cardiovascular diseases, although the precise mechanism is unknown. We investigated the effect of EPA on the regression of atherosclerosis. METHODS AND RESULTS: LDL-receptor-deficient mice were fed a high-cholesterol diet for 8 weeks to build up aortic sinus atherosclerotic lesions and then were fed a normal diet with or without...
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