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Article

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response.

Journal of cell science - 1 Sept 2010

Malzer Elke, Daly Marie-Louise, Moloney Aileen, Sendall Timothy J, Thomas Sally E, Ryder Edward, Ryoo Hyung Don, Crowther Damian C, Lomas David A, Marciniak Stefan J

Abstract excerpt

The integrated stress response (ISR) protects cells from numerous forms of stress and is involved in the growth of solid tumours; however, it is unclear how the ISR acts on cellular proliferation. We have developed a model of ISR signalling with which to study its effects on tissue growth. Overexpression of the ISR kinase PERK resulted in a striking atrophic eye phenotype in Drosophila melanogaster that could be...

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Identifiers

PMID: 20682638
DOI: 10.1242/jcs.070078
PMCID: PMC2923568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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