Article
The Neurospora checkpoint kinase 2: a regulatory link between the circadian and cell cycles.
Science (New York, N.Y.) - 4 Aug 2006
Pregueiro António M, Liu Qiuyun, Baker Christopher L, Dunlap Jay C, Loros Jennifer J
Abstract excerpt
The clock gene period-4 (prd-4) in Neurospora was identified by a single allele displaying shortened circadian period and altered temperature compensation. Positional cloning followed by functional tests show that PRD-4 is an ortholog of mammalian checkpoint kinase 2 (Chk2). Expression of prd-4 is regulated by the circadian clock and, reciprocally, PRD-4 physically interacts with the clock component FRQ,...
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