Article
The Neurospora checkpoint kinase 2: a regulatory link between the circadian and cell cycles.
Science (New York, N.Y.) - 4 Aug 2006
Pregueiro António M, Liu Qiuyun, Baker Christopher L, Dunlap Jay C, Loros Jennifer J
Abstract excerpt
The clock gene period-4 (prd-4) in Neurospora was identified by a single allele displaying shortened circadian period and altered temperature compensation. Positional cloning followed by functional tests show that PRD-4 is an ortholog of mammalian checkpoint kinase 2 (Chk2). Expression of prd-4 is regulated by the circadian clock and, reciprocally, PRD-4 physically interacts with the clock component FRQ,...
Topics
- Amino Acid Sequence
- Cell Cycle
- Checkpoint Kinase 2
- Circadian Rhythm
- Cloning, Molecular
- DNA Damage
- Feedback, Physiological
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Methyl Methanesulfonate