Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins

22 Jun 2011

Abstract excerpt

Cyclin-dependent kinase subunit (Cks) proteins are small cyclin-dependent kinase-interacting proteins that are frequently overexpressed in breast cancer, as well as in a broad spectrum of other human malignancies. However, the mechanistic link between Cks protein overexpression and oncogenesis is still unknown. In this work, we show that overexpression of Cks1 or Cks2 in human mammary epithelial and breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21697511
DOI: 10.1073/pnas.1102434108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteinsPMID 21697511Read ↗

Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic InstabilitySemantic proximity Read ↗

Coming of Age: Targeting Cyclin K in CancersSemantic proximity Read ↗

CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer TherapySemantic proximity Read ↗

DNA replication stress: oncogenes in the spotlightSemantic proximity Read ↗

DNA replication stress: oncogenes in the spotlightSemantic proximity Read ↗

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.Semantic proximity Read ↗

Reviewing cancer’s biology: an eclectic approachSemantic proximity Read ↗

CKS2 in human cancers: Clinical roles and current perspectives (Review)Semantic proximity Read ↗

Biological functions and therapeutic potential of CKS2 in human cancerSemantic proximity Read ↗

Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast CancerSemantic proximity Read ↗

A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing drugs in RB1-deficient ovarian and breast cancer cellsSemantic proximity Read ↗

Cyclins and related kinases in cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.