Article

A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant co-stabilization of cyclin D1 and p21

2022-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Nucleotide excision repair (NER) eliminates highly-genotoxic solar UV-induced DNA photoproducts that otherwise stimulate malignant melanoma development. Here, a genome-wide loss-of-function screen, coupling CRISPR/Cas9 technology with a flow cytometry-based DNA repair assay, was used to identify novel genes required for efficient NER in primary human fibroblasts. Interestingly, the screen reveal...

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Literature Corpus work: 6b763c29-de41-56fc-bd5e-961788e65850
DOI: 10.1101/2022.04.14.488378

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